Perspectivum - Scientific animation briefings

12 articles

Immunotherapy Phase II Featured

CAR-T Cell Trafficking Across the Blood-Tumour Barrier

Animated reconstruction of chimeric antigen receptor T-cell extravasation, tumour infiltration, and antigen-dependent cytotoxic killing in a solid-tumour microenvironment.

Perspectivum 631, 88-96 (2024) · 10.1038/s41586-024-07201-1 · NCT05812040

4:12

Gene Therapy Phase I/II

CRISPR-Cas9 Base Editing in Sickle Cell Disease

Mechanistic animation of adenine base editing at the HBB locus, depicting guide RNA binding, adenosine deaminase activity, and haemoglobin switching in erythroid progenitors.

Perspectivum 629, 401-410 (2024) · 10.1038/s41586-024-07122-z · NCT05572814

3:50

Oncology Phase III Featured

PD-1/PD-L1 Checkpoint Blockade in Non-Small Cell Lung Cancer

Visualisation of tumour-infiltrating lymphocyte reinvigoration following pembrolizumab administration, including TCR signalling cascade and apoptotic target engagement.

Perspectivum 624, 55-64 (2023) · 10.1038/s41586-023-06894-5 · NCT04604210

5:20

Pharmacology Preclinical

mRNA Lipid Nanoparticle Endosomal Escape

Molecular dynamics-informed animation of ionisable lipid nanoparticle uptake, late endosome acidification, membrane fusion, and cytoplasmic mRNA release.

Perspectivum 630, 577-585 (2024) · 10.1038/s41586-024-07251-5 · NCT05434832

2:58

Oncology Phase II

Antibody-Drug Conjugate Bystander Killing

Step-by-step animation of ADC binding at HER2 antigen, lysosomal linker cleavage, payload release, and membrane-permeable toxin diffusion to antigen-negative neighbouring cells.

Perspectivum 628, 903-911 (2024) · 10.1038/s41586-024-07089-9 · NCT05168891

3:35

Cell Biology Phase II

Senescent Cell Clearance by Senolytics

Visualisation of dasatinib and quercetin disruption of pro-survival BCL-2 networks in p16-positive senescent stromal cells, triggering selective apoptosis and SASP resolution.

Perspectivum 620, 487-495 (2023) · 10.1038/s41586-023-06371-z · NCT04063124

4:05

Neurology Phase II Featured

Tau Propagation in Alzheimer’s Disease

Trans-synaptic spread of misfolded tau seeds across hippocampal circuits, depicting uptake mechanisms, templated misfolding, and Braak stage progression.

Perspectivum 627, 760-769 (2024) · 10.1038/s41586-024-07063-7 · NCT05026866

6:00

Gene Therapy Phase III

AAV9 Gene Transfer in Spinal Muscular Atrophy

Intravenous administration, retrograde motor neuron tropism, nuclear import, and episomal SMN1 transgene expression in lumbar anterior horn cells following onasemnogene abeparvovec delivery.

Perspectivum 619, 31-41 (2023) · 10.1038/s41586-023-06328-2 · NCT03505073

4:48

Immunotherapy Phase I

Macrophage Polarisation in Tumour Microenvironment

Dynamic switching between M1 and M2 macrophage states in response to CSF-1R inhibition, IFN-gamma signalling, and metabolic reprogramming within the glioblastoma niche.

Perspectivum 631, 284-292 (2024) · 10.1038/s41586-024-07318-3 · NCT04599712

3:20

Cell Biology Preclinical

Clathrin-Mediated Receptor Internalisation

Live-cell fluorescence reconstruction of EGFR clustering, clathrin lattice assembly, dynamin-driven vesicle scission, and endosomal sorting following EGF stimulation.

Perspectivum 621, 733-741 (2023) · 10.1038/s41586-023-06441-2

2:30

Oncology Phase II

Bi-specific T-cell Engager Synapse Formation

Blinatumomab-mediated formation of a cytolytic immune synapse between CD3+ T cells and CD19+ B-cell lymphoma targets, with perforin and granzyme B secretion dynamics.

Perspectivum 629, 622-630 (2024) · 10.1038/s41586-024-07145-6 · NCT04546126

3:15

Neurology Preclinical

Neuroinflammation: Microglial Phagocytosis of Synapses

C1q-tagged synapse recognition, tethered phagocytic cup extension, and lysosomal digestion by activated microglia in a murine model of complement-driven synaptic loss.

Perspectivum 622, 215-223 (2023) · 10.1038/s41586-023-06512-4

4:22